Biomarker development and discovery

Biomarkers map the molecular signatures of disease. A complete understanding of gene expression, the presence of certain proteins, and the complex networks that drive biological function, may someday result in a "personalized medical profile" to prevent, diagnose, and treat disease in each patient. Battelle-Japan's molecular biology team is at the cutting edge of this exciting field of research. Using state-of-the-art facilities and expertise in current nucleic acid and recombinant DNA technologies, Battelle-Japan provides services in:

• PCR and Microarray reagent development
• Gene Expression/Analysis and support of developmental bioinformatics
• Recombinant DNA services
• Vector Development
• Cloning
• cDNA library construction and screening
• DNA sequencing

Medical devices for diagnostics and therapeutics

With access to 75,000 square foot ISO 9001:2000 facility, including a prototype model shop, machine shop, electronics laboratory, and non-contact inspection laboratory, Battelle-Japan can provide full-service product development expertise for partners and clients. Our services and experience includes:

• Complex Electromechanical Products/Systems (software, human factors, user interface, engineering design for very tight packaging)
• High Volume Consumables (design for cost efficiency, manufacturability)
• Manufacturing Systems (manual fixtures, semi-automated stations, and fully automated)
• Imaging Systems (algorithms, target handling and staging, systems integration) Manufacturing Systems for Cellular Therapy Products

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Toxicology

Accessing Battelle's leadership in performing studies for the U.S. government, private sector companies, and international companies who are interested in the human health effects of tobacco, air pollution, and nanoparticles, Battelle-Japan provides innovative solutions in:

• Safety Pharmacology
• Cardiovascular and Respiratory Physiology
• Pulmonary Delivery
• Nonclinical Safety Assessment

Bioinformatics

To improve the throughput of drug discovery, Battelle-Japan offers the robust computational tools that enable biologists to answer complex biological questions. Software programs linking scientific applications and heterogeneous data sources automate otherwise costly, time-consuming molecular profiling data analysis. Our services include:

• Automated data gathering
• Bioinformatics tool interfaces
• Data Extraction and Integration

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